ÿþ<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN"> <!-- saved from url=(0041)file://\\Nazi\e\sol-end\eng-maghale-2.htm --> <HTML><HEAD><TITLE>Professor Soltanzadeh</TITLE> <META http-equiv=Content-Type content="text/html; charset=unicode"> <META content="Microsoft FrontPage 5.0" name=GENERATOR> <META content=FrontPage.Editor.Document name=ProgId></HEAD> <BODY text=#000000 vLink=#ff0000 aLink=#0000ff link=#0000ff bgProperties=fixed bgColor=#ffffff leftMargin=0 background="foriegnarticle2_files/bg4 copy.gif" topMargin=0> <DIV align=left> <TABLE height=61 cellSpacing=0 cellPadding=0 width=706 border=0> <TBODY> <TR> <TD vAlign=bottom align=justify width=166 height=1><IMG height=140 src="foriegnarticle2_files/toppage3.gif" width=166 border=0></TD> <TD width=673 background=foriegnarticle2_files/bgew.gif height=1> <DIV align=left> <TABLE height=136 cellSpacing=0 cellPadding=0 border=0 width="613"> <TBODY> <TR> <TD colSpan=4 height=46 width="290"> <P align=center><IMG height=36 src="foriegnarticle2_files/Toptext7.gif" width=255 border=0></P></TD> <TD height=46 width="50"></TD> <TD height=46 width="45"></TD> <TD height=46 width="120"></TD> <TD colSpan=2 height=46 width="118"><IMG height=40 src="foriegnarticle2_files/inkscroll.gif" width=65 align=right border=0></TD></TR> <TR> <TD height=36 width="40"><a href="tamas.htm"><IMG height=30 src="foriegnarticle2_files/But8copy.gif" width=40 border=0></a></TD> <TD height=36 width="80"><a href="karhay.htm"><IMG height=30 src="foriegnarticle2_files/But7copy.gif" width=80 border=0></a></TD> <TD height=36 width="115"><a href="tarh.htm"><IMG height=30 src="foriegnarticle2_files/b1.gif" width=115 border=0></a></TD> <TD height=36 width="55"><a href="maghale.htm"><IMG height=30 src="foriegnarticle2_files/b2.gif" width=55 border=0></a></TD> <TD height=36 width="50"><a href="kongereh.htm"><IMG height=30 src="foriegnarticle2_files/But4copy.gif" width=50 border=0></a></TD> <TD height=36 width="45"><a href="talifat.htm"><IMG height=30 src="foriegnarticle2_files/But3copy.gif" width=45 border=0></a></TD> <TD height=36 width="120"><a href="moarefi.htm"><IMG height=30 src="foriegnarticle2_files/But1copy.gif" width=120 border=0></a></TD> <TD vAlign=bottom height=36 width="84"><a href="index.htm"><IMG height=30 src="foriegnarticle2_files/But10copy.gif" width=80 border=0></a>&nbsp;</TD> <TD height=36 width="34">&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR> <TR> <TD align=left colSpan=9 height=54 width="623"><BR> <p class="MsoNormal" style="text-autospace: none" align="center"> <span style="font-family: Arial; font-weight: 700">Transcutaneous Bilirubin Measurement: A Multicenter Evaluation <br>of a New Device</span></TD></TR></TBODY></TABLE></DIV></TD></TR> <TR> <TD vAlign=top align=justify width=166 height=180><IMG height=174 src="foriegnarticle2_files/toppage1.gif" width=114 align=top border=0></TD> <TD width=673 height=180> <DIV align=left> <TABLE cellSpacing=0 cellPadding=4 width=587> <TBODY> <TR> <TD width="579"> <p align="center"><BR><font color="#000080" size="2"> <span style="font-family: Arial">Firmino F. Rubaltelli, MD*; Glenn R. Gourley , MD ;Norbert Loskamp, MDS; Neena Modi,MB,ChB,MD,FRCP; Matthias Roth-Kleiner ,MD ;Alfred Sender, MD#; and Paul Vert, MD**</span></font></p> <p><FONT color=#00006a>&nbsp;</FONT><TR> <TD width="579"> <P align=left><B><FONT face=Homa color=#003300 size=3>ABSTRACT <P align=left></FONT></B><span style="font-family: Arial"> Objectives. The early discharge of neonates from hospitals makes transcutaneous measurement of total bilirubin concentration a useful tool to monitor neonatal jaundice. The objectives of this study were to determine whether 1)&nbsp; transcutaneous bilirubin (TcB) measurement, as performed using BiliCheck(BC), correlates with total serum bilirubin (TSB) levels, measured with standard laboratory methods and with high-pressure liquid chromatography (HPLC-B); 2) infant race, gestational age, postnatal age, or body weight interferes with the measurement of TcB levels in newborn infants; 3) the variability of the TcB measurement is comparable to the variability of TSB measurements; and 4) TcB measurements obtained from the forehead (BCF) and sternum (BCS) generate comparable results.</span><p class="MsoNormal" style="text-autospace: none"> <span style="font-family: Arial">study Design. Newborn infants who were &lt;28 days and&gt; 30 weeks&#39; gestational age and who underwent tests for TSB as part of their normal care in 6 different European hospitals were studied. A total of 210 infants were enrolled in the study, 35 at each site. Near simultaneous (within +_ 30 minutes) blood collection for TSB and BCF and BCS measurements were performed. TSB levels were determined by the serum bilirubin method in use at each site, and all HPLC-B determinations were made at the same, independent laboratory.</span></p> <p class="MsoNormal" style="text-autospace: none"> <span style="font-family: Arial">Results. The study group consisted of 140 white, 31 Asian, 14 Hispanic, 9 African, and another 16 newborns of different race. The correlation confficient (r) between BCF and HPLC-B was 0.890 (95% confidence interval= 0.858-0.915). BCF and BCS generated similar results (r value= 0.890 for BCF and 0.881 for BCS), even if BCS slightly overestimated (mean error = -0.04 mg/dL) and BCF slightly underestimated (mean error= 0.96 mg/dL) in comparison with HPLC-B. Analysis of covariance demonstrated that BC accuracy was independent of race, birth weight, gestational age , and postnatal age of the newborn. Receiver operathing characteristic curves were evaluated for BCF and TSB, each compared with HPLC-B. with the use of a cutoff point for HPLC-B of 13 mg/dL (222 </span> <span style="font-family: Symbol; color: black">m</span><span style="font-family: Arial"> mol/L) and a cutoff of 11 mg/dL on the BCF and TSB, similar sensitivity/specificity (93%/73% for BCF, 95%/76% for TSB) were observed. The use of a cutoff point for HPLC-B of 17 mg/dL(290 </span><span style="font-family: Symbol; color: black">m</span><span style="font-family: Arial"> mol/L)&nbsp; and 14 mg/dL(240 </span> <span style="font-family: Symbol; color: black">m</span><span style="font-family: Arial"> mol/L)&nbsp; for BCF and TSB also produced similar sensitivity/specificity (90%/87% for the Bc and 87%/83% for TSB).</span></p> <p class="MsoNormal" style="text-autospace: none"> <span style="font-family: Arial">Conclusions. Because the correlation coefficient for HPLC-B and BCF is very similar to that found for HPLC-B and laboratory TSB,BC could be used not only as a screening device but also as a reliable substitute of TSB determination. At higher levels of TSB,in which phototherapy and/or exchange transfusion might be considered , BC performed slightly better than the laboratory . The accuracy and precision of the TcB measurement in this study was observed to be comparable to the standard of care laboratory test. Pediatrics 2001;107:1264-1271;jaundice, newborn, bilirubin, Kernicterus, transutaneous bilirubin measurement, laboratory bilirubin determination.</span></p> <hr> <p class="MsoNormal" style="text-autospace: none"> <span style="font-family: Arial; font-weight: 700"><font size="2"> ABBREVIATIONS. TSB, total serum bilirubin;BC BiliCheck;TcB , transutaneous bilirubin; HPLC-B, high-pressure liquid chromatography bilirubin;BCF, BiliChek forehead;BCS,BiliCheck sternum;SD,standard deviation; ROC, receiver operating characteristic;CI, 95%confidence inteval.</font></span></p> <hr> <p class="MsoNormal" style="text-autospace: none"> <font color="#008000" size="2"> <span style="font-family:Arial">PEDIATRICS Vol. 107 No. 6 June 2001</span></font></TR></TBODY></TABLE></DIV><BR><BR> <DIV align=left> <TABLE height=67 cellSpacing=0 cellPadding=0 width=599 border=0> <TBODY> <TR> <TD width=579 height=65> <P class=MsoNormal dir=rtl style="MARGIN-BOTTOM: -15px; DIRECTION: rtl; unicode-bidi: embed; mso-pagination: none; mso-layout-grid-align: none" align=center><a href="index.htm">Home page</a>&nbsp; |&nbsp;<a href="eng-moarefi.htm">Introduction</a>&nbsp;|&nbsp;<a href="eng-tarh.htm"> Research Studies</a>&nbsp; |&nbsp;<a href="eng-talifat.htm"> Editorships</a>&nbsp; |&nbsp;<a href="eng-translate.htm"> Translations</a>&nbsp; |&nbsp;<a href="eng-kongereh.htm"> Conferences</a>&nbsp; </P> <P class=MsoNormal dir=rtl style="MARGIN-BOTTOM: -15px; DIRECTION: rtl; unicode-bidi: embed; mso-pagination: none; mso-layout-grid-align: none" align=center><a href="eng-tamas.htm">Contact Information</a>&nbsp; |&nbsp;<a href="eng-maghale.htm"> Articles</a>&nbsp; |&nbsp;<a href="news.htm"> Scientific meets &amp; events</a>&nbsp; |&nbsp;<a href="research.htm"> Research projects</a>&nbsp; |&nbsp; Theses</P></TD></TR></TBODY></TABLE></DIV></TD></TR></TBODY></TABLE></DIV></BODY></HTML>